ENDOCRINE DISRUPTORS - Denmark contributes to the development of strategies to identify substances that can interfere with the hormone systems
Information and data required by the European chemicals legislative framework, in particular REACH,
the Plant Protection Products Regulation (PPPR) and the Biocidal Products Regulation (BPR),
are considered to be
insufficient to adequately detect substances with endocrine
disrupting properties (i.e.
that can interfere with the hormone systems of humans and other mammals).
Common
criteria to define endocrine disrupting substances are currently
debated in Europe.
Denmark has proposed to the DGs Health, Environment and Enterprise of
the European Commission a
set of strategies for the establishment of new criteria to identify substances
with endocrine disrupting properties. Results of a study showing the
effectiveness
of the proposed criteria are also provided. The proposal contains specific
recommendations
for data requirements to be introduced in REACH, PPPR and BPR, as well as
suggestions on
standard test methods.
A “test package” that includes OECD TG 234 and/or TG 443 is suggested.
The prioritization should be based on alerts of endocrine effects raised by QSARs, read across, and
in vitro data as well as all any other available information.
The report is the outcome of a project, conducted by the Centre on Endocrine Disrupters (CeHoS) for the
Danish Environmental Protection Agency. The objective was to provide a science-based input
to the ongoing work on endocrine disruptors with regard to various legislative frameworks.
Related links
- Danish report:
"Information/testing strategy for identification of
substances with endocrine disrupting properties"
-
DK EPA press release